Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application

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Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application

Research into human biotransformation and elimination systems continues to evolve. Various clinical and in vivo studies have been undertaken to evaluate the effects of foods and food-derived components on the activity of detoxification pathways, including phase I cytochrome P450 enzymes, phase II conjugation enzymes, Nrf2 signaling, and metallothionein. This review summarizes the research in th...

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Comment on “Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application”

The article " Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application " is misleading in its title and the discussion does not fit this title. This narrative review article presents a comprehensive review of food and food components on specific metabolic detoxification pathways (phase I cytochrome enzymes, phase II c...

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EXECUTIVE SUMMARY The sheer volume to which humans are exposed to environmental toxicants and biological toxins on a daily basis can overburden the body’s natural metabolic detoxification capacity. Mounting evidence has suggested that the accumulation of toxins is associated with a number of chronic conditions, and lifestyle and nutrition have critical roles in minimizing toxicant and toxin exp...

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ژورنال

عنوان ژورنال: Journal of Nutrition and Metabolism

سال: 2015

ISSN: 2090-0724,2090-0732

DOI: 10.1155/2015/760689